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In an effort to protect us from getting killed by something we’ve ingested, our brain’s vomit control center processes a lot of information from several different places … and sometimes is a little overly cautious.
LEARN MORE
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To learn more about this topic, start your googling with these keywords:
- Emesis: The act of vomiting
- Vomiting: The oral eviction of gastrointestinal contents due to contractions in the gut and stomach.
- Nausea: A diffuse sensation of uneasiness and discomfort often felt as the need to vomit.
- Vomiting Center: An area in the brain’s medulla oblongata that initiates and controls emesis.
- Chemoreceptor Trigger Zone: An area in the area postrema of the medulla oblongata that is sensitive to certain toxic chemicals in the blood.
- Nucleus Tractus Solitarius: A region in the medulla oblongata that receives input from the cardiovascular, respiratory and GI systems.
- Vagus Nerve: A cranial nerve that regulates internal organ functions, including vomiting.
- Vestibular System: A Sensory system that provides our brain with information about motion, head position, and spatial positioning for balance.
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CREDITS
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David Goldenberg | Script Writer, Narrator and Director
Arcadi Garcia i Rius | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music
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REFERENCES
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Singh P, Yoon SS, Kuo B. Nausea: a review of pathophysiology and therapeutics. Therap Adv Gastroenterol. 2016;9(1):98-112. Retrieved from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699282/
Hasler, W. (2013). Pathology of emesis: its autonomic basis. Handbook of Clinical Neurology, Vol. 117 (3rd series) Autonomic Nervous System. Retrieved from:
https://pubmed.ncbi.nlm.nih.gov/24095137/
Zhong W, Shahbaz O, Teskey G, Beever A, Kachour N, Venketaraman V, Darmani NA. Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems. Int J Mol Sci. 2021 May 28;22(11):5797. Retrieved from:
https://pubmed.ncbi.nlm.nih.gov/34071460/
Kowalski A, Rapps N, Enck P. Functional cortical imaging of nausea and vomiting: a possible approach. Auton Neurosci. 2006 Oct 30;129(1-2):28-35. Retrieved from:
https://pubmed.ncbi.nlm.nih.gov/16945593/
Hornby, PJ. Central neurocircuitry associated with emesis. Am J Med. 2001 Dec 3;111 Suppl 8A:106S-112S. Retrieved from:
https://pubmed.ncbi.nlm.nih.gov/11749934/
Kuo, Braden. (2022). Personal Communication. Director of the Center for Neurointestinal Health at Mass General.
https://www.massgeneral.org/doctors/17189/brad-kuo.
https://www.youtube.com/embed/t0O2kSFVjm4
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